Blood as a mirror of the brain
The researchers, led by Dennis van ’t Ent and with Pedro Sant’Anna Barbosa Ferreira as the primary executing researcher, examined biological aging in both blood and the brain. They found that the rate at which the packaging of DNA in blood cells ages is related to the rate of brain aging. "This aligns with indications from previous research. It is encouraging to find this relationship, as it suggests that blood tests could potentially be used in the future to measure brain aging. This could serve as an accessible and cost-effective alternative to brain scans," said Van ’t Ent.Environment influences brain aging
The study was conducted with twins, allowing scientists to determine the extent to which genetic and environmental factors influence brain aging. The results show that environmental factors support the connection between aging in blood and brain. Van ’t Ent stated, "More research is needed to identify exactly which environmental influences play a role and at what age. These could include lifestyle factors such as healthy nutrition and sufficient physical activity, but also influences present from birth."Impact on healthcare
As the population ages, the risk of age-related brain diseases increases. This research contributes to a better understanding of how brain aging can be influenced and possibly slowed down. By learning more about relevant environmental factors and their timing, preventive measures can be implemented. This could reduce pressure on healthcare systems and help people remain mentally fit for longer.The study was conducted using data from 254 participants from the Netherlands Twin Register, ranging in age from 20 to 84 years. Scientists used MRI brain scans and specialized DNA measurements in blood to determine the participants’ biological age.
